This narrative review summarizes a selection of clinically-important novel gastrointestinal developments, presented and discussed at the virtual Gastro Update Europe.The selected topics, fully referenced, reflect what the distinguished faculty considered of vital importance to be communicated to the astute busy gastro-hep clinician who is eager to stay abreast of important novel developments. Whenever appropriate a personal comment or ...

This narrative review summarizes a selection of recent, clinically-important novel gastrointestinal developments, presented and discussed at the European Gastro Update In Budapest. The selected topics reflect what the distinguished faculty considered of vital importance to be communicated to the astute busy gastro-hep clinician, who is eager to stay well informed of important novel developments in his discipline. Whenever appropriate a personal ...

Surveillance recommendations, according to ESGE guidelines vary according to the length of the Barrett segment. Surveillance varies from: none for <10 mm; every 5 y for <3 cm; every 3 y for <10 cm; and surveillance in a Barrett expert center if >10 cm. Difference in expertise between a community hospital and an expert center was analysed in a retrospective multi-centric study involving 198 patients with high-grade ...

The incidence of colorectal cancer in individuals <50 years old is on the rise, related perhaps to the obesity epidemic and increased frequency of germline genetic changes. A large retrospective ana­lysis was carried out in 430 young colorectal cancer patients. 20% carried germline mutations asso­ciated with cancer predisposition (mostly mutations in Lynch MMR, but also APC gene and other variants). Importantly, half of the individuals with ...

Massive hypertriglyceridemia is a well established cause of acute pancreatitis. Less clear is the role of lower triglyceride levels. In an impressive prospective study, sequential triglyceride levels were determined in 116,550 individuals during a mean follow-up of 6.7 years. As shown below, pancreatitis risk increased by 20% when triglyceride levels rose by 100 mg/dl; for comparison, the rising risk of myocardial infarction is also shown (JAMA ...

Celiac disease remains the dominant small intestinal pathology. Can celiac disease also be diagnosed in adults without histology as recommended in the “biopsy-sparing” guidelines for children? A recent study revealed that high anti-tissue transglutaminase and anti-endomisial antibodies in HLA-DQ2/DQ8 symptomatic patients correlated with villous atrophy in over 90%, and that increasing levels of anti-tissue transglutaminase were paralleled by ...